The notion that completing the course of an antibiotic reduces the emergence of bacterial resistance is not accepted anymore. From in vitro evidence, we know that prolonged exposure to antibiotic , particularly at low levels (as occurs for instance in the oropharynx of patients treated with most oral antibiotics) is a good way to breed bacteria that are resistant – mutational change and horizontal gene transfers are potentiated by the stress induced by antibiotic exposure. Antibiotic presence provides a selective advantage for resistant sub-populations that then become dominant.
Abdomen/GIT Allergy AMS strategy Antibiograms Antimicrobial Bloodstream CNS Infections Dentistry General Practice Guidelines Health Pathology NSW HNE LHD Hospital practice Infection prevention Journal paper Microbiology Myths & Misconceptions News Patient information Respiratory Salutary tale SexuallyTxDis Skin/soft tissue Uncategorized Urinary tract infections Weird facts
Top Posts & Pages
- Q10 - Remembering antibiotics and their classes
- Is it cellulitis? The case of itchy red legs
- What is the most abundant organism on Earth? Not what you'd think!
- Sparing fluoroquinolones - alternative safe and effective options by syndrome and bug
- Flucloxacillin is highly effective against Streptococcus pyogenes (group A strep) and related species
- Is it really cellulitis? - differential diagnosis of a red leg
- Why do Gram positive and Gram negative bacteria show different antibiotic susceptibility patterns?
- Patient advice: recurrent staphylococcal infection
- Piperacillin+tazobactam shortage - recommended alternatives - HNELHD
- Maximising the value of blood cultures
02 4014 3695