Category Hospital practice
Updated overview of approaches to CRE treatment
Guest posting from Professors Josh Davis (Hunter New England Health) and Patrick Harris (UQ). AMBLER CLASS Class A Class B Class D Key characteristic Serine group enzyme Metallo-betalactamase OXA-type Key example(s) KPC, GES IMP, NDM, VIM OXA-48. (OXA-181, OXA-232 emerging) Susceptiblity features R to all b-lactams R to all b-lactams except Aztreonam May harbour other […]
Top 10 Infectious Diseases papers 2022 – Prof Josh Davis
Here is Josh’s eclectic selection of top non-COVID papers for 2022! Top ID papers of 2022 Davis Happy New Year all from AIMED.
Viral Hepatitis and HIV Prescribing Summary
Guest posting from A/Prof Josh Davis, Newcastle. Image credit: https://www.hepatitisc.uw.edu/go/treatment-infection/treatment-genotype-3/core-concept/all 2020
Essential clinical care of Staphylococcus aureus bloodstream infection (SAB)
Originally posted on AIMED – Let's talk about antibiotics:
Updated 8/5/20. A. Healthcare-associated events (2018, HNE LHD ) 60 healthcare-associated SAB cases occurred with 7% due to methicillin-resistant Staphylococcus aureus (MRSA) and age-adjusted 30 day mortality of 9%. SAB relapse within 15-90 days occurred in 2.1% of adult events 7% of paediatric events. Principle…
How long should that antibiotic course last?
Guest posting from Ms Kristi Kozierowski, AMS and ICU pharmacist, John Hunter Hospital, NSW, Australia. This is a useful evidence-based summary produced for AAW 2019 – Duration FINAL Kozierowski 2019. Usage welcome with acknowledgement. References Shorter is better : evidence review by Brad Spellberg
Smartphone website for local guidelines including pneumonia (HNELHD)
The Quality Use of Medicines smartphone-enabled website has been updated to include changes to hospital acquired pneumonia guidelines. With this site, you are only three clicks away from a treatment recommendation! See below for the range of guidelines available. Note that whilst Therapeutic Guidelines: Antibiotic remains the main resource, HNE guidelines, where approved, take precedence- […]
Acute piperacillin+tazobactam shortage – important advice – JHH and HNELHD
Currently (still in Feb 2018) there is a worldwide shortage of piperacillin+tazobactam , an additional issue to the shortage earlier in 2017 . Appropriate substitutions – see – HNELHD advice (November 2017) JHH_Pip_Taz_Fact_Sheet_Oct_2017 . This includes new dosage recommendations for IV amox+clavulanate for intra-abdominal infection (6 -hrly rather than 8- hrly dosing). For further advice, please contact the […]
Do we need to cover ‘atypical’ community acquired pneumonia?
Guest posting: Dr John Burston, Staff Specialist, Infectious Diseases, Calvary Mater Hospital, Newcastle. Most antibiotic guidelines1-3 , including the HNELHD Community Acquired Pneumonia (CAP) guideline, suggest empirically treating community acquired pneumonia (CAP) with a macrolide or tetracycline to cover ‘atypical’ organisms. But is this necessary and what should be our approach? Beta-lactam monotherapy was non-inferior […]
Small joint septic arthritis: a different management paradigm
Guest posting: Dr Jonathan Ash, Infectious Diseases Registrar, John Hunter Hospital, Newcastle, NSW. A recent single centre retrospective case series from Switzerland examined the clinical characteristics, microbiology and treatment of 97 patients with small native joint septic arthritis. The paper highlights significant differences in the pathogenesis of small joint septic arthritis compared to large joints, […]