Overuse => global shortage! Let’s conserve what piperacillin+tazobactam we have left

Piperacillin+tazobactam (Tazocin) is one of our most important broad spectrum agents and is in short supply.

Please conserve it by avoiding use in these common situations:

  • Uncomplicated biliary sepsis  (Use ampicillin+gentamicin(max 48hrs) OR if allergic, ceftriaxone)
  • Urinary tract infection with sepsis (Use ampicillin+gentamicin(max 48 hrs) OR if allergic, ceftriaxone)
  • Early onset (< 5d after admission) ICU -associated pneumonia or ward onset hospital acquired pneumonia (any time period after admission) (Use augmentin oral/IV OR benzylpenicillin+gentamicin)
  • Community acquired pneumonia  (For moderate CAP, use  benzylpenicillin+doxycycline, severe CAP-  benpen+gentamicin_azithromycin)

Also see this AIMED article on Tazocin misuse in community-acquired pneumonia.

Note:  For late onset (> 5 days after admission) ICU-associated pneumonia use of piperacillin+tazobactam is appropriate in the HNELHD setting.

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